The contribution of inflammatory astrocytes to BBB impairments in a brain-chip model of Parkinson's disease.

ABSTRACT: Astrocyte dysfunction has previously been linked to multiple neurodegenerative disorders including Parkinson's disease (PD). Among their many roles, astrocytes are mediators of the brain immune response, and astrocyte reactivity is a pathological feature of PD. They are also involved in the formation and maintenance of the blood-brain barrier (BBB), but barrier integrity is compromised in people with PD. This study focuses on an unexplored area of PD pathogenesis by characterizing the interplay between astrocytes, inflammation and BBB integrity, and by combining patient-derived induced pluripotent stem cells with microfluidic technologies to generate a 3D human BBB chip. Here we report that astrocytes derived from female donors harboring the PD-related LRRK2 G2019S mutation are pro-inflamm

SUBMITTER: de Rus Jacquet A 

PROVIDER: S-EPMC10282096 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature