Transcriptomic and in vivo approaches introduced human iPSC-derived microvesicles for skin rejuvenation.

ABSTRACT: The skin undergoes the formation of fine lines and wrinkles through the aging process; also, burns, trauma, and other similar circumstances give rise to various forms of skin ulcers. Induced pluripotent stem cells (iPSCs) have become promising candidates for skin healing and rejuvenation due to not stimulating inflammatory responses, low probability of immune rejection, high metabolic activity, good large-scale production capacity and potentials for personalized medicine. iPSCs can secrete microvesicles (MVs) containing RNA and proteins responsible for the normal repairing process of the skin. This study aimed to evaluate the possibility, safety and effectiveness of applying iPSCs-derived MVs for skin tissue engineering and rejuvenation applications. The possibility was assessed using the

SUBMITTER: Bakhshandeh B 

PROVIDER: S-EPMC10282097 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature