Lipids, lipid-lowering agents, and inflammatory bowel disease: a Mendelian randomization study.

ABSTRACT:

Background

To assess the causal role of lipid traits and lipid-lowering agents in inflammatory bowel disease (IBD).

Methods

Univariable mendelian randomization (MR) and multivariable MR (MVMR) analyses were conducted to evaluate the causal association between low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and IBD. Drug-targeted MR analyzed the effects of lipid-lowering drugs on IBD, and network MR was used to analyze potential mediation effects.

Results

The levels of HDL-C had an inverse relationship with the risk of Crohn's disease (CD, OR: 0.85, 95% CI: 0.73-0.98, P = 0.024). In MVMR, the inverse relationships were found in all three outcomes. Drug-targeted MR analyses showed that with one-SD LDL-

SUBMITTER: Tao H 

PROVIDER: S-EPMC10282130 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature