Gut microbiota and intestinal barrier function in subjects with cognitive impairments: a cross-sectional study.

ABSTRACT:

Background

Gut-brain axis might play an important role in cognitive impairments by various diseases including Alzheimer's disease (AD).

Objective

To investigate the differences in gut microbial composition, intestinal barrier function, and systemic inflammation in patients with AD or mild cognitive impairment (MCI), and normal control (NC) cases.

Methods

A total of 118 subjects (45 AD, 38 MCI, and 35 NC) were recruited. Cognitive function was assessed using Mini-Mental State Examination (MMSE), and Montreal Cognitive Assessment Scale (MoCA). Functional ability was assessed using Activity of Daily Living Scale (ADL). The composition of gut microbiome was examined by 16S rRNA high-throughput sequencing. Phylogenetic Investigation of Communities by Reconstruction of Unob

SUBMITTER: Pei Y 

PROVIDER: S-EPMC10282132 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature