The folate status of reproductive-aged women in a randomised trial of a folate-fortified oral contraceptive: dietary and blood assessments.

ABSTRACT:

Objective

To assess the folate status of US women in a study of a folate-fortified oral contraceptive (OC) using the Short Folate Food Frequency Questionnaire and plasma and red blood cell (RBC) folate samples.

Design

Sub-analysis from a multi-centre, randomised, double-blind, controlled contraceptive trial with assessments at baseline and 6 months. We calculated dietary folate equivalents (DFE) consumed and the proportion of participants meeting folate adequacy benchmarks.

Setting

Eight centres in the USA.

Subjects

Healthy women aged 18-40 years requesting contraception with no contraindications for OC use.

Results

Overall, 385 participants were randomised to either a novel folate-fortified OC or a marketed OC. The 262 (68 %) participants compliant with

SUBMITTER: Castano PM 

PROVIDER: S-EPMC10282410 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature