Transcriptome-wide association study reveals novel susceptibility genes for coronary atherosclerosis.

ABSTRACT:

Background

Genetic risk factors substantially contributed to the development of coronary atherosclerosis. Genome-wide association study (GWAS) has identified many risk loci for coronary atherosclerosis, but the translation of these loci into therapeutic targets is limited for their location in non-coding regions. Here, we aimed to screen the potential coronary atherosclerosis pathogenic genes expressed though TWAS (transcriptome wide association study) and explore the underlying mechanism association.

Methods

Four TWAS approaches (PrediXcan, JTI, UTMOST, and FUSION) were used to screen genes associated with coronary atherosclerosis. Enrichment analysis of TWAS-identified genes was applied through the Metascape website. The summary-data-based Mendelian randomization (SMR) ana

SUBMITTER: Zhao Q 

PROVIDER: S-EPMC10282549 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature