Myocardial capacity of mitochondrial oxidative phosphorylation in response to prolonged electromagnetic stress.

ABSTRACT:

Introduction

Mitochondria are central energy generators for the heart, producing adenosine triphosphate (ATP) through the oxidative phosphorylation (OXPHOS) system. However, mitochondria also guide critical cell decisions and responses to the environmental stressors.

Methods

This study evaluated whether prolonged electromagnetic stress affects the mitochondrial OXPHOS system and structural modifications of the myocardium. To induce prolonged electromagnetic stress, mice were exposed to 915 MHz electromagnetic fields (EMFs) for 28 days.

Results

Analysis of mitochondrial OXPHOS capacity in EMF-exposed mice pointed to a significant increase in cardiac protein expression of the Complex I, II, III and IV subunits, while expression level of α-subunit of ATP synthase (Comple

SUBMITTER: Savchenko L 

PROVIDER: S-EPMC10282661 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature