Visual disability in neuromyelitis optica spectrum disorders: prognostic prediction models.

ABSTRACT:

Background and objectives

Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disease of the central nervous system characterized by simultaneous or consecutive episodes of acute optic neuritis and transverse myelitis. Attacks of NMOSD can result in the accrual of severe visual disability over time. This study aimed to develop and validate prognostic models for visual disability risk within 1, 3, and 5 years.

Methods

Medical records of NMOSD patients were retrospectively analyzed. The least absolute shrinkage and selection operator (LASSO) regression algorithm and univariate and multivariate Cox regression analyses were performed to select predictors of visual disability. Two models predicting the probability of visual disability in 1, 3, and 5 years

SUBMITTER: Luo W 

PROVIDER: S-EPMC10282746 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature