Prognostic analysis of patients with breast cancer based on tumor mutational burden and DNA damage repair genes.

ABSTRACT:

Background

Breast cancer has a high tumor-specific death rate and poor prognosis. In this study, we aimed to provide a basis for the prognostic risk in patients with breast cancer using significant gene sets selected by analyzing tumor mutational burden (TMB) and DNA damage repair (DDR).

Methods

Breast cancer genomic and transcriptomic data were obtained from The Cancer Genome Atlas (TCGA). Breast cancer samples were dichotomized into high- and low-TMB groups according to TMB values. Differentially expressed DDR genes between high- and low-TMB groups were incorporated into univariate and multivariate cox regression model to build prognosis model. Performance of the prognosis model was validated in an independently new GEO dataset and evaluated by time-dependent ROC curves.

SUBMITTER: Teng X 

PROVIDER: S-EPMC10282748 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature