New Bacteriophages Members of the Ackermannviridae Family Specific for Klebsiella pneumoniae ST258.

ABSTRACT:

Background

Carbapenem-resistant Klebsiella pneumoniae, particularly isolates classified as sequence-type 258 (ST258), are multidrug-resistant strains that are strongly associated with poor-prognosis nosocomial infections, as current therapeutic options are limited and ineffective. In recent years, phage therapy has emerged as a promising treatment option for these scenarios.

Methodology and results

We report the isolation and characterization of three new phages against Klebsiella pneumoniae ST258 strains recovered from Machángara river wastewater. These new members of the Ackermannviridae family showed stability over a wide temperature and pH range and burst sizes ranging from 6 to 44 plaque-forming units per bacteria. Their genomes were about 157 kilob

SUBMITTER: Tisalema-Guanopatin E 

PROVIDER: S-EPMC10282792 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature