Mixed Feedings and Necrotizing Enterocolitis: The Proportion of Human Milk Matters.

ABSTRACT: Objectives: Impact of the proportion of human milk (HM) in mixed feeding on necrotizing enterocolitis (NEC) remains unknown. This study explores the influence of different proportions of HM on the risk of NEC. Materials and Methods: A retrospective cohort study was performed in infants with very low birth weight (VLBW). A spline smoothing curve was used to evaluate the dose-dependent association between HM and the risk of NEC. Univariate and multivariate analyses were performed to detect the association between the proportion of HM and NEC. Results: Twenty-four infants developed NEC, with 4 (1.9%) in the high HM group, 18 (28.1%) in the low HM group, and 2 (8.0%) in the exclusive formula group (p < 0.001). After adjusting for the relevant co

SUBMITTER: Xiong X 

PROVIDER: S-EPMC10282811 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature