Effect of a low versus intermediate tidal volume strategy on pulmonary complications in patients at risk of acute respiratory distress syndrome-a randomized clinical trial.

ABSTRACT:

Introduction

There is no consensus on whether invasive ventilation should use low tidal volumes (V_T) to prevent lung complications in patients at risk of acute respiratory distress syndrome (ARDS). The purpose of this study is to determine if a low V_T strategy is more effective than an intermediate V_T strategy in preventing pulmonary complications.

Methods

A randomized clinical trial was conducted in invasively ventilated patients with a lung injury prediction score (LIPS) of >4 performed in the intensive care units of 10 hospitals in Spain and one in the United States of America (USA) from 3 November 2014 to 30 August 2016. Patients were randomized to invasive ventilation using low V_T (≤ 6 mL/kg predicted body weight, PBW) (N</

SUBMITTER: de Haro C 

PROVIDER: S-EPMC10282840 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature