Evidence of Lack of Treatment Efficacy Derived From Statistically Nonsignificant Results of Randomized Clinical Trials.

ABSTRACT:

Importance

Many randomized clinical trials yield statistically nonsignificant results. Such results are difficult to interpret within the dominant statistical framework.

Objective

To estimate the strength of evidence in favor of the null hypothesis of no effect vs the prespecified effectiveness hypothesis among nonsignificant primary outcome results of randomized clinical trials by application of the likelihood ratio.

Design, setting, and participants

Cross-sectional study of statistically nonsignificant results for primary outcomes of randomized clinical trials published in 6 leading general medical journals in 2021.

Outcome measures

The likelihood ratio for the null hypothesis of no effect vs the effectiveness hypothesis stated in the trial protocol (alternat

SUBMITTER: Perneger T 

PROVIDER: S-EPMC10282886 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature