Fetal genome predicted birth weight and polycystic ovary syndrome in later life: a Mendelian randomization study.

ABSTRACT: Associations between lower birth weight and higher polycystic ovary syndrome (PCOS) risk have been reported in previous observational studies, however, the causal relationship is still unknown. Based on decomposed fetal and maternal genetic effects on birth weight (n  =  406,063), we conducted a two-sample Mendelian randomization (MR) analysis to assess potential causal relationships between fetal genome predicted birth weight and PCOS risk using a large-scale genome-wide association study (GWAS) including 4,138 PCOS cases and 20,129 controls. To further eliminate the maternally transmitted or non-transmitted effects on fetal growth, we performed a secondary MR analysis by utilizing genetic instruments after excluding maternally transmitted or non-transmitted variants, which were identifie

SUBMITTER: Liu D 

PROVIDER: S-EPMC10282929 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature