Metrics of dose to highly ventilated lung are predictive of radiation-induced pneumonitis in lung cancer patients.

ABSTRACT:

Purpose

To identify metrics of radiation dose delivered to highly ventilated lung that are predictive of radiation-induced pneumonitis.

Methods and materials

A cohort of 90 patients with locally advanced non-small cell lung cancer treated with standard fractionated radiation therapy (RT) (60-66 Gy in 30-33 fractions) were evaluated. Regional lung ventilation was determined from pre-RT 4-dimensional computed tomography (4DCT) using the Jacobian determinant of a B-spline deformable image registration to estimate lung tissue expansion during respiration. Multiple voxel-wise population- and individual-based thresholds for defining high functioning lung were considered. Mean dose and volumes receiving dose ≥ 5-60 Gy were analyzed for both total lung-ITV (MLD,V5-V60) and highly ve

SUBMITTER: Flakus MJ 

PROVIDER: S-EPMC10283046 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature