The metallic compound promotes primordial follicle activation and ameliorates fertility deficits in aged mice.

ABSTRACT: Background: Aged women and premature ovarian insufficiency (POI) patients have residual dormant primordial follicles that are hard to be activated through a physiological process. However, there are no effective and safe drugs to help them. Methods: We used the in vitro culture model of newborn mouse ovaries to identify the drugs that promote primordial follicle activation and study its mechanisms. It was verified by in vivo injection model of newborn mice and in vitro culture model of human ovarian tissue. In addition, we used the aged mice as a low infertility model to verify the effects of primordial follicle activation, and fertility by drugs. Results: Eleven metallic compounds activated mouse primordial follicles, and the five most effective c

SUBMITTER: Han L 

PROVIDER: S-EPMC10283063 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature