Dietary cobalt oxide nanoparticles alleviate aging through activation of mitochondrial UPR in Caenorhabditis elegans.

ABSTRACT: Mitochondrial unfolded protein response (UPR^mt), which is a mitochondrial proteostasis pathway, orchestrates an adaptive reprogramming for metabolism homeostasis and organismal longevity. Similar to other defense systems, compromised UPR^mt is a feature of several age-related diseases. Here we report that dimercapto succinic acid (DMSA)-modified cobalt oxide nanoparticles (Co₃O₄ NPs), which have received wide-spread attention in biomedical fields, is a promising UPR^mt activator and, more importantly, provides a gate for extending healthy lifespan. Methods: UPR^mt activation by Co₃O₄ NPs was tested in transgenetic Caenorhabditis elegans (C. elegans) specifically expressing UPR^mt</

SUBMITTER: Cong W 

PROVIDER: S-EPMC10283066 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature