MASH Native: a unified solution for native top-down proteomics data processing.

ABSTRACT:

Motivation

Native top-down proteomics (nTDP) integrates native mass spectrometry (nMS) with top-down proteomics (TDP) to provide comprehensive analysis of protein complexes together with proteoform identification and characterization. Despite significant advances in nMS and TDP software developments, a unified and user-friendly software package for analysis of nTDP data remains lacking.

Results

We have developed MASH Native to provide a unified solution for nTDP to process complex datasets with database searching capabilities in a user-friendly interface. MASH Native supports various data formats and incorporates multiple options for deconvolution, database searching, and spectral summing to provide a "one-stop shop" for characterizing both native protein complexes and prote

SUBMITTER: Larson EJ 

PROVIDER: S-EPMC10283151 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature