The role of small airway function parameters in preschool asthmatic children.

ABSTRACT:

Background

Small airways are the major sites of inflammation and airway remodeling in all severities of asthma patients. However, whether small airway function parameters could reflect the airway dysfunction feature in preschool asthmatic children remain unclear. We aim to investigate the role of small airway function parameters in evaluating airway dysfunction, airflow limitation and airway hyperresponsiveness (AHR).

Methods

Eight hundred and fifty-one preschool children diagnosed with asthma were enrolled retrospectively to investigate the characteristics of small airway function parameters. Curve estimation analysis was applied to clarify the correlation between small and large airway dysfunction. Spearman's correlation and receiver-operating characteristic (ROC) curves w

SUBMITTER: Yi L 

PROVIDER: S-EPMC10283187 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature