A streptavidin-biotin system combined with magnetic actuators for remote neuronal guidance.

ABSTRACT: The ability to control neuronal mobility and organization is of great importance in developing neuronal interfaces and novel therapeutic approaches. An emerging promising method is the manipulation of neuronal cells from afar via magnetic forces. Nevertheless, using magnetic iron oxide nanoparticles as internal actuators may lead to biotoxicity, adverse influence on intracellular processes, and thus requires prerequisite considerations for therapeutic approaches. Magnetizing the cells via the incorporation of magnetic particles that can be applied extracellularly is advantageous. Herein, we have developed a magnetic system based on streptavidin-biotin interaction to decorate cellular membrane with magnetic elements. In this model, superparamagnetic microparticles, coated with streptavidin,

SUBMITTER: Levenberg DR 

PROVIDER: S-EPMC10283188 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature