Metabolic engineering of Escherichia coli for high-level production of violaxanthin.

ABSTRACT:

Background

Xanthophylls are a large class of carotenoids that are found in a variety of organisms and play particularly important roles in the light-harvesting and photoprotection processes of plants and algae. Violaxanthin is an important plant-derived xanthophyll with wide potential applications in medicines, foods, and cosmetics because of its antioxidant activity and bright yellow color. To date, however, violaxanthins have not been produced using metabolically engineered microbes on a commercial scale. Metabolic engineering for microbial production of violaxanthin is hindered by inefficient synthesis pathway in the heterologous host. We systematically optimized the carotenoid chassis and improved the functional expression of key enzymes of violaxanthin biosynthesis in Escheric

SUBMITTER: Xinrui D 

PROVIDER: S-EPMC10283192 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature