Fluralaner (Bravecto^®) treatment kills Aedes aegypti after feeding on Dirofilaria immitis-infected dogs.

ABSTRACT:

Background

Transmission of canine heartworm (Dirofilaria immitis) from infected to naïve dogs is dependent on successful mosquito feeding and survival.

Methods

To determine whether treating heartworm-infected dogs with fluralaner (Bravecto^®) limits the survival of infected mosquitoes, and potentially the transmission of D. immitis, we allowed female mosquitoes to feed on microfilaremic dogs and evaluated mosquito survival and infection with D. immitis. Eight dogs were experimentally infected with D. immitis. On day 0 (~ 11 months post-infection), four microfilaremic dogs were treated with fluralaner according to label directions while the other four were non-treated controls. Mosquitoes (Aedes aegypti Liverpool) were allowed to feed on each dog on days -7, 2, 30,

SUBMITTER: Duncan K 

PROVIDER: S-EPMC10283246 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature