Pathological ultrastructural alterations of myelinated axons in normal appearing white matter in progressive multiple sclerosis.

ABSTRACT: Multiple sclerosis (MS) pathophysiology includes inflammation, demyelination and neurodegeneration, but the exact mechanisms of disease initiation and progression are unknown. A major feature of lesions is lack of myelin, which increases axonal energy demand and requires adaptation in number and size of mitochondria. Outside lesions, subtle and diffuse alterations are observed in normal appearing white matter (NAWM) and normal appearing grey matter (NAGM), including increased oxidative stress, reduced axon density and changes in myelin composition and morphology. On an ultrastructural level, only limited data is available on alterations in myelinated axons. We generated large scale 2D scanning transmission electron microscopy images ('nanotomy') of non-demyelinated brain tissue of control

SUBMITTER: Oost W 

PROVIDER: S-EPMC10283269 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature