BCAT1 controls embryonic neural stem cells proliferation and differentiation in the upper layer neurons.

ABSTRACT: The regulation of neural stem cell (NSC) proliferation and differentiation during brain development is a precisely controlled process, with the production of different neuronal subtypes governed by strict timelines. Glutamate is predominantly used as a neurotransmitter by the subtypes of neurons in the various layers of the cerebral cortex. The expression pattern of BCAT1, a gene involved in glutamate metabolism, in the different layers of neurons has yet to be fully understood. Using single-cell data, we have identified seven different states of NSCs and found that state 4 is closely associated with the development of projection neurons. By inferring the developmental trajectory of different neuronal subtypes from NSC subsets of this state, we discovered that BCAT1 is involved in the regu

SUBMITTER: Zhang S 

PROVIDER: S-EPMC10283284 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature