Epidemiological and transcriptome data identify potential key genes involved in iron overload for type 2 diabetes.

ABSTRACT:

Background

Many previous studies have reported the association between iron overload (IO) and type 2 diabetes mellitus (T2DM). However, the underlying molecular mechanism is not clear.

Methods

Epidemiological data from the National Health and Nutrition Examination Survey 2017-2018 (NHANES) was used to systematically explore the association between IO and diabetes. Furthermore, transcriptome data from Gene Expression Omnibus (GEO) were analyzed using bioinformatics methods to explore the underlying functional mechanisms at the molecular level.

Results

Data from NHANES showed a "W" shape relationship between serum iron (frozen) and the risk of diabetes (P < 0.001) as well as a "∧" shape correlation between serum unsaturated iron binding capacity (UIBC) and the risk of d

SUBMITTER: Liu X 

PROVIDER: S-EPMC10283296 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature