Prevalence of MMTV-like sequences in breast cancer samples in Romanian patients-there is a geographic difference compared to the Western world.

ABSTRACT:

Background

Breast cancer, although the most frequently diagnosed malignant tumor in humans, has a less clear etiology compared to other frequent cancer types. Mouse-mammary tumor virus (MMTV) is involved in breast cancer in mice and dogs and might play a role in the etiology of some breast cancers in humans, since an MMTV-like sequence was identified in 20-40% of breast cancer samples in Western Europe, USA, Australia and some other parts of the world. The purpose of our study was to identify MMTV-like DNA sequences in breast tissue samples from breast cancer patients who underwent curative surgery in our regional academic center in Romania, EU.

Methods

We selected 75 patients with non-metastatic breast cancer treated surgically with curative intent, who did not undergo any

SUBMITTER: Fekete Z 

PROVIDER: S-EPMC10283304 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature