Hormonal and inflammatory signatures of different mood episodes in bipolar disorder: a large-scale clinical study.

ABSTRACT:

Background

Bipolar disorder (BD) is characterized by intensive mood fluctuations. While hormones imbalance plays important role in the mood swings, it is unknown whether peripheral hormones profiles could differentiate the manic and depressive mood episodes in BD. In this study, we investigated the changes of various hormones and inflammatory markers across distinct mood episodes of BD in a large clinical study to provide mood episode-specific peripheral biomarkers for BD.

Methods

A total of 8332 BD patients (n = 2679 depressive episode; n = 5653 manic episode) were included. All patients were in acute state of mood episodes and need hospitalization. A panel of blood tests were performed for levels of sex hormones (serum levels of testosterone, estradiol, and progesterone),

SUBMITTER: Lyu N 

PROVIDER: S-EPMC10283309 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature