Single-cell expression profile of Drosophila ovarian follicle stem cells illuminates spatial differentiation in the germarium.

ABSTRACT:

Background

How stem cell populations are organized and regulated within adult tissues is important for understanding cancer origins and for developing cell replacement strategies. Paradigms such as mammalian gut stem cells and Drosophila ovarian follicle stem cells (FSC) are characterized by population asymmetry, in which stem cell division and differentiation are separately regulated processes. These stem cells behave stochastically regarding their contributions to derivative cells and also exhibit dynamic spatial heterogeneity. Drosophila FSCs provide an excellent model for understanding how a community of active stem cells maintained by population asymmetry is regulated. Here, we use single-cell RNA sequencing to profile the gene expression patterns of FSCs and their immediate d

SUBMITTER: Dong Z 

PROVIDER: S-EPMC10283321 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature