Current status of genome-wide epigenetic profiling of mammalian preimplantation embryos.

ABSTRACT:

Background

Genome-wide information on epigenetic modifications in mammalian preimplantation embryos was an unexplored sanctuary of valuable research insights protected by the difficulty of its analysis. However, that is no longer the case, and many epigenome maps are now available for sightseeing there.

Methods

This review overviews the current status of genome-wide epigenetic profiling in terms of DNA methylome and histone modifications in mammalian preimplantation embryos.

Main findings

As the sensitivity of methods for analyzing epigenetic modifications increased, pioneering work began to explore the genome-wide epigenetic landscape in the mid-2010s, first for DNA methylation and then for histone modifications. Since then, a huge amount of data has accumulated, rev

SUBMITTER: Ikeda S 

PROVIDER: S-EPMC10283350 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature