Coumestrol induces oxidative stress and impairs migration and embryonic growth.

ABSTRACT:

In brief

Healthy development of the placenta is dependent on trophoblast cell migration and reduced oxidative stress presence. This article describes how a phytoestrogen found in spinach and soy causes impaired placental development during pregnancy.

Abstract

Although vegetarianism has grown in popularity, especially among pregnant women, the effects of phytoestrogens in placentation lack understanding. Factors such as cellular oxidative stress and hypoxia and external factors including cigarette smoke, phytoestrogens, and dietary supplements can regulate placental development. The isoflavone phytoestrogen coumestrol was identified in spinach and soy and was found to not cross the fetal-placental barrier. Since coumestrol could be a valuable supplement or potent toxin during

SUBMITTER: Marbrey MW 

PROVIDER: S-EPMC10283428 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature