Phosphorylation of EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha) is indispensable for nuclear translocation of TFEB and TFE3 during ER stress.
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ABSTRACT:
SUBMITTER: Dang TT
PROVIDER: S-EPMC10283430 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
Publications
Phosphorylation of EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha) is indispensable for nuclear translocation of TFEB and TFE3 during ER stress.
Dang Thao Thi TT Kim Mi-Jeong MJ Lee Yoon Young YY Le Hien Thi HT Kim Kook Hwan KH Nam Somi S Hyun Seung Hwa SH Kim Hong Lim HL Chung Su Wol SW Chung Hun Taeg HT Jho Eek-Hoon EH Yoshida Hiderou H Kim Kyoungmi K Park Chan Young CY Lee Myung-Shik MS Back Sung Hoon SH
Autophagy 20230209 7
There are diverse links between macroautophagy/autophagy pathways and unfolded protein response (UPR) pathways under endoplasmic reticulum (ER) stress conditions to restore ER homeostasis. Phosphorylation of EIF2S1/eIF2α is an important mechanism that can regulate all three UPR pathways through transcriptional and translational reprogramming to maintain cellular homeostasis and overcome cellular stresses. In this study, to investigate the roles of EIF2S1 phosphorylation in regulation of autophag ...[more]
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