Incidence of Breast Cancer in the Life Span Study of Atomic Bomb Survivors: 1958-2009.

ABSTRACT: The importance of reproductive history in breast tissue development and etiology of sporadic breast cancer in females is well established. However, there is limited evidence of factors, other than age, that modify risk of radiation-related breast cancer. In this study, we evaluated breast cancer incidence in the Life Span Study cohort of atomic bomb survivors, adding 11 years of follow-up and incorporating reproductive history data. We used Poisson regression models to describe radiation risks and modifying effects of age and reproductive factors. Among 62,534 females, we identified 1,470 breast cancers between 1958 and 2009. Of 397 new cases diagnosed since 1998, 75% were exposed before age 20. We found a strong linear dose response with excess relative risk (ERR) of 1.12 per Gy [95% conf

SUBMITTER: Brenner AV 

PROVIDER: S-EPMC10284068 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature