Optimizing Precision Medicine for Breast Cancer Brain Metastases with Functional Drug Response Assessment.

ABSTRACT: The development of novel therapies for brain metastases is an unmet need. Brain metastases may have unique molecular features that could be explored as therapeutic targets. A better understanding of the drug sensitivity of live cells coupled to molecular analyses will lead to a rational prioritization of therapeutic candidates. We evaluated the molecular profiles of 12 breast cancer brain metastases (BCBM) and matched primary breast tumors to identify potential therapeutic targets. We established six novel patient-derived xenograft (PDX) from BCBM from patients undergoing clinically indicated surgical resection of BCBM and used the PDXs as a drug screening platform to interrogate potential molecular targets. Many of the alterations were conserved in brain metastases compared with the match

SUBMITTER: Morikawa A 

PROVIDER: S-EPMC10284082 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature