Palladium mono-N-protected amino acid complexes: experimental validation of the ligand cooperation model in C-H activation.

ABSTRACT: Mechanistic proposals for the C-H activation reaction enabled by mono-N-protected amino acid ligands (MPAAs) have been supported by DFT calculations. The direct experimental observation of the ligand-assisted C-H activation has not yet been reported due to the lack of well-defined isolated palladium complexes with MPAAs that can serve as models. In this work, palladium complexes bearing chelating MPAAs (NBu₄)[Pd(κ²-N,O-AcN-CHR-COO)(C₆F₅)py] (Ac = MeC(O); R = H, Me) and [Pd(κ²-N,O-MeNH-CH₂-COO)(C₆F₅)py] have been isolated and characterized. Their evolution in a solution containing toluene leads to the C-H activation of the arene and the formation of the C₆F

SUBMITTER: Fernandez-Moyano S 

PROVIDER: S-EPMC10284104 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature