Proton-Only Sensing of Hyperpolarized [1,2-¹³C₂]Pyruvate.

ABSTRACT: Hyperpolarized MRI is emerging as a next-generation molecular imaging modality that can detect metabolic transformations in real time deep inside tissue and organs. ¹³C-hyperpolarized pyruvate is the leading hyperpolarized contrast agent that can probe cellular energetics in real time. Currently, hyperpolarized MRI requires specialized "multinuclear" MRI scanners that have the ability to excite and detect ¹³C signals. The objective of this work is the development of an approach that works on conventional (i.e., proton-only) MRI systems while taking advantage of long-lived ¹³C hyperpolarization. The long-lived singlet state of [1,2-¹³C₂]pyruvate is hyperpolarized with parahydrogen in reversible exchange, and subsequently, the polarizati

SUBMITTER: Mandzhieva I 

PROVIDER: S-EPMC10284333 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature