A dynamic calcium-force relationship model for sag behavior in fast skeletal muscle.

ABSTRACT: In vitro studies using isolated or skinned muscle fibers suggest that the sigmoidal relationship between the intracellular calcium concentration and force production may depend upon muscle type and activity. The goal of this study was to investigate whether and how the calcium-force relationship changes during force production under physiological conditions of muscle excitation and length in fast skeletal muscles. A computational framework was developed to identify the dynamic variation in the calcium-force relationship during force generation over a full physiological range of stimulation frequencies and muscle lengths in cat gastrocnemius muscles. In contrast to the situation in slow muscles such as the soleus, the calcium concentration for the half-maximal force needed to drift rightwar

SUBMITTER: Kim H 

PROVIDER: S-EPMC10284414 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature