Sequential involvements of the perirhinal cortex and hippocampus in the recall of item-location associative memory in macaques.

ABSTRACT: The standard consolidation theory suggests that the hippocampus (HPC) is critically involved in acquiring new memory, while storage and recall gradually become independent of it. Converging studies have shown separate involvements of the perirhinal cortex (PRC) and parahippocampal cortex (PHC) in item and spatial processes, whereas HPC relates the item to a spatial context. These 2 strands of literature raise the following question; which brain region is involved in the recall process of item-location associative memory? To solve this question, this study applied an item-location associative (ILA) paradigm in a single-unit study of nonhuman primates. We trained 2 macaques to associate 4 visual item pairs with 4 locations on a background map in an allocentric manner before the recording ses

SUBMITTER: Yang C 

PROVIDER: S-EPMC10284415 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature