Viral proteogenomic and expression profiling during productive replication of a skin-tropic herpesvirus in the natural host.

ABSTRACT: Efficient transmission of herpesviruses is essential for dissemination in host populations; however, little is known about the viral genes that mediate transmission, mostly due to a lack of natural virus-host model systems. Marek's disease is a devastating herpesviral disease of chickens caused by Marek's disease virus (MDV) and an excellent natural model to study skin-tropic herpesviruses and transmission. Like varicella zoster virus that causes chicken pox in humans, the only site where infectious cell-free MD virions are efficiently produced is in epithelial skin cells, a requirement for host-to-host transmission. Here, we enriched for heavily infected feather follicle epithelial skin cells of live chickens to measure both viral transcription and protein expression using combined short-

SUBMITTER: Volkening JD 

PROVIDER: S-EPMC10284419 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature