Podoplanin and CLEC-2 levels in patients with COVID-19.

ABSTRACT:

Introduction

Podoplanin (PDPN gene) and CLEC-2 are involved in inflammatory hemostasis and have also been related with the pathogenesis of thrombosis. Emerging evidence also suggest that podoplanin can exert protective effects in sepsis and in acute lung injury. In lungs, podoplanin is co-expressed with ACE2, which is the main entry receptor for SARS-CoV-2.

Aim

To explore the role of podoplanin and CLEC-2 in COVID-19.

Methods

Circulating levels of podoplanin and CLEC-2 were measured in 30 consecutive COVID-19 patients admitted due to hypoxia, and in 30 age- and sex-matched healthy individuals. Podoplanin expression in lungs from patients who died of COVID-19 was obtained from two independent public databases of single-cell RNAseq from which data from control lu

SUBMITTER: Borba-Junior IT 

PROVIDER: S-EPMC10284445 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature