Association of Early Serum Phosphate Levels and Mortality in Patients with Sepsis.

ABSTRACT:

Background

Metabolic derangements in sepsis influence phosphate levels, which may predict mortality outcomes. We investigated the association between initial phosphate levels and 28-day mortality in patients with sepsis.

Methods

We conducted a retrospective analysis of patients with sepsis. Initial (first 24 hours) phosphate levels were divided into phosphate quartile groups for comparisons. We used repeated-measures mixed-models to assess differences in 28-day mortality across the phosphate groups, adjusting for other predictors identified by the Least Absolute Shrinkage and Selection Operator variable selection technique.

Results

A total of 1,855 patients were included with 13% overall 28-day mortality (n=237). The highest phosphate quartile (>4.0 milligrams per dec

SUBMITTER: Black LP 

PROVIDER: S-EPMC10284527 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature