Ontology highlight
ABSTRACT:
SUBMITTER: Levin SN
PROVIDER: S-EPMC10284549 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Levin Solomon N SN Tomasini Michael D MD Knox James J Shirani Mahsa M Shebl Bassem B Requena David D Clark Jackson J Heissel Søren S Alwaseem Hanan H Surjan Rodrigo R Lahasky Ron R Molina Henrik H Torbenson Michael S MS Lyons Barbara B Migler Rachael D RD Coffino Philip P Simon Sanford M SM
Science advances 20230621 25
Fibrolamellar hepatocellular carcinoma (FLC) is a usually lethal primary liver cancer driven by a somatic dysregulation of protein kinase A. We show that the proteome of FLC tumors is distinct from that of adjacent nontransformed tissue. These changes can account for some of the cell biological and pathological alterations in FLC cells, including their drug sensitivity and glycolysis. Hyperammonemic encephalopathy is a recurrent problem in these patients, and established treatments based on the ...[more]