Blue-ringed octopus-inspired microneedle patch for robust tissue surface adhesion and active injection drug delivery.

ABSTRACT: Intratissue topical medication is important for the treatment of cutaneous, mucosal or splanchnic diseases. However, penetrating surface barriers to providing adequate and controllable drug delivery while guaranteeing adhesion in bodily fluids remains challenging. Here, the predatory behavior of the blue-ringed octopus inspired us with a strategy to improve topical medication. For effective intratissue drug delivery, the active injection microneedles were prepared in a manner inspired by the teeth and venom secretion of blue-ringed octopus. With on demand release function guided by temperature-sensitive hydrophobic and shrinkage variations, these microneedles can supply adequate drug delivery at an early stage and then achieve the long-term release stage. Meanwhile, the bionic suction cups

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC10284554 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature