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Zinc curcumin complex on fluoride doped hydroxyapatite with enhanced biological properties for dental and orthopedic applications.

ABSTRACT: Since antiquity, curcumin, from turmeric is utilized in traditional Indian medicine (Ayurveda) to treat bone disorders. However, the hydrophobic nature and poor absorption of curcumin limit its clinical applications. There is a need to develop a novel strategy that can significantly enhance curcumin's biological properties. The current work reports the utilization of Zn²⁺-curcumin complex from a fluoride doped hydroxyapatite matrix for osteosarcoma inhibition, osteoblast growth, and anti-bacterial properties. The interaction between Zn²⁺ and curcumin increases curcumin release by ~ 2.5 folds. The fabricated drug delivery system shows up to ~ 1.6 times enhancement in osteoblast cell viability. The presence of curcumin results in ~ 4 times more osteosarcoma inhibition compared to control. The antibacterial efficacy of this system is confirmed against Staphylococcus aureus, due to the presence of antibacterial fluoride, zinc, and curcumin. This multifunctional drug delivery system can be utilized for various bone-tissue engineering and dental applications.

SUBMITTER: Bhattacharjee A

PROVIDER: S-EPMC10284581 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Zinc curcumin complex on fluoride doped hydroxyapatite with enhanced biological properties for dental and orthopedic applications.

Bhattacharjee Arjak A Bose Susmita S

Journal of materials research 20220629 12

Since antiquity, curcumin, from turmeric is utilized in traditional Indian medicine (<i>Ayurveda</i>) to treat bone disorders. However, the hydrophobic nature and poor absorption of curcumin limit its clinical applications. There is a need to develop a novel strategy that can significantly enhance curcumin's biological properties. The current work reports the utilization of Zn<sup>2+</sup>-curcumin complex from a fluoride doped hydroxyapatite matrix for osteosarcoma inhibition, osteoblast growth ...[more]

PMID: 37346089

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Project description:BackgroundThere has been little application of fluorine-substituted hydroxyapatites (FHAs) in dental adhesives. Previous studies primarily focused on the effect of fluoride content on enamel remineralization, neglecting the role of FHA particle size. This study aimed to synthesize uniform FHA nanorods of varying sizes by adjusting the fluorine doping levels, and to investigate the synergistic effects of the fluorine content and nanorod size on enamel remineralization by incorporating the FHA nanorods into adhesives.MethodsFHA nanorods with varying fluorine doping levels and sizes were synthesized based on a hydrothermal method. The characterization analyses of FHA nanorods were demonstrated by X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and transmission electron microscopy (TEM). The composite adhesives containing 10 wt% different FHA nanorods were characterized via scanning electron microscopy (SEM). The colloidal stability, light-curing poperties, and degree of conversion (DC %) were assessed. The shear bond strength (SBS) was determined and the failure mode analysis was reported. The release of Ca2+ and F- within 30 days was detected. The remineralization was evaluated via SEM, energy dispersive X-ray spectroscopy (EDS), XRD, and micro-hardness through in vitro and in vivo experiments. Statistical analyses were performed using the Shapiro-Wilk test, Levene test, one-way ANOVA, Tukey HSD method, Welch test, Tamhane test, Fisher's exact test and Kruskal-Wallis test (α = 0.05).ResultsUniform FHA nanorods of varying sizes were synthesized by adjusting the fluorine doping level (2 wt%, 6 wt%, and 10 wt%). The lengths of these FHA nanorods were 505.31 ± 104.43 nm, 111.27 ± 22.89 nm, and 66.21 ± 12.68 nm, respectively. The composite adhesives containing FHA nanorods showed good colloidal stability and appropriate light-curing properties. The SBS of composite adhesives decreased due to the incorporation of FHA nanorods, but the values still remained within the clinically required range. Three groups of the composite adhesives could release Ca2+ and F- continuously. The group of 10 wt% F-doped HA nanorods with shorter lengths exhibited more mineral deposition and absorption of Ca²⁺ onto the adhesive and enamel surfaces.ConclusionsThe strategy of adding the synthesized FHA nanorods into dental adhesives can be an effective approach to promote enamel remineralization, while maintaining adequate bond strength. The 10 wt% F-doped HA nanorods with shorter lengths exhibited superior remineralization.

Dataset Information

Zinc curcumin complex on fluoride doped hydroxyapatite with enhanced biological properties for dental and orthopedic applications.

Publications

Zinc curcumin complex on fluoride doped hydroxyapatite with enhanced biological properties for dental and orthopedic applications.

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