Gut microbial GABAergic signaling improves stress-associated innate immunity to respiratory viral infection.

ABSTRACT:

Introduction

Epidemiological evidences reveal that populations with psychological stress have an increased likelihood of respiratory viral infection involving influenza A virus (IAV) and SARS-CoV-2.

Objectives

This study aims to explore the potential correlation between psychological stress and increased susceptibility to respiratory viral infections and how this may contribute to a more severe disease progression.

Methods

A chronic restraint stress (CRS) mouse model was used to infect IAV and estimate lung inflammation. Alveolar macrophages (AMs) were observed in the numbers, function and metabolic-epigenetic properties. To confirm the central importance of the gut microbiome in stress-exacerbated viral pneumonia, mice were conducted through microbiome depletion and

SUBMITTER: Gao Y 

PROVIDER: S-EPMC10284622 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature