Entropic repulsion of cholesterol-containing layers counteracts bioadhesion.

ABSTRACT: Control of adhesion is a striking feature of living matter that is of particular interest regarding technological translation^1-3. We discovered that entropic repulsion caused by interfacial orientational fluctuations of cholesterol layers restricts protein adsorption and bacterial adhesion. Moreover, we found that intrinsically adhesive wax ester layers become similarly antibioadhesive when containing small quantities (under 10 wt%) of cholesterol. Wetting, adsorption and adhesion experiments, as well as atomistic simulations, showed that repulsive characteristics depend on the specific molecular structure of cholesterol that encodes a finely balanced fluctuating reorientation at the interface of unconstrained supramolecular assemblies: layers of cholesterol analogues differing

SUBMITTER: Friedrichs J 

PROVIDER: S-EPMC10284698 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature