Ultraviolet radiation shapes dendritic cell leukaemia transformation in the skin.

ABSTRACT: Tumours most often arise from progression of precursor clones within a single anatomical niche. In the bone marrow, clonal progenitors can undergo malignant transformation to acute leukaemia, or differentiate into immune cells that contribute to disease pathology in peripheral tissues^1-4. Outside the marrow, these clones are potentially exposed to a variety of tissue-specific mutational processes, although the consequences of this are unclear. Here we investigate the development of blastic plasmacytoid dendritic cell neoplasm (BPDCN)-an unusual form of acute leukaemia that often presents with malignant cells isolated to the skin⁵. Using tumour phylogenomics and single-cell transcriptomics with genotyping, we find that BPDCN arises from clonal (premalignant) haematopoi

SUBMITTER: Griffin GK 

PROVIDER: S-EPMC10284703 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature