Polygenic scoring accuracy varies across the genetic ancestry continuum.

ABSTRACT: Polygenic scores (PGSs) have limited portability across different groupings of individuals (for example, by genetic ancestries and/or social determinants of health), preventing their equitable use^1-3. PGS portability has typically been assessed using a single aggregate population-level statistic (for example, R²)⁴, ignoring inter-individual variation within the population. Here, using a large and diverse Los Angeles biobank⁵ (ATLAS, n = 36,778) along with the UK Biobank⁶ (UKBB, n = 487,409), we show that PGS accuracy decreases individual-to-individual along the continuum of genetic ancestries⁷ in all considered populations, even within traditionally labelled 'homogeneous' genetic ancestries. The decreasing trend is well capt

SUBMITTER: Ding Y 

PROVIDER: S-EPMC10284707 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature