In silico mutagenesis-based designing of oncogenic SHP2 peptide to inhibit cancer progression.

ABSTRACT: Cancer is among the top causes of death, accounting for an estimated 9.6 million deaths in 2018, it appeared that approximately 500,000 people die from cancer in the United States alone annually. The SHP2 plays a major role in regulation of cell growth, proliferation, and differentiation, and functional upregulation of this enzyme is linked to oncogenesis and developmental disorders. SHP2 activity has been linked to several cancer types for which no drugs are currently available. In our study, we aimed to design peptide inhibitors against the SHP2 mutant. The crystal structure of the human Src SH2-PQpYEEIPI peptide mutant was downloaded from the protein databank. We generated several peptides from the native wild peptide using an in silico mutagenesis method, which showed that changes (P30

SUBMITTER: Shahab M 

PROVIDER: S-EPMC10284847 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature