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Robust statistical properties of T1 transitions in a multi-phase field model of cell monolayers.

ABSTRACT: Large-scale tissue deformation which is fundamental to tissue development hinges on local cellular rearrangements, such as T1 transitions. In the realm of the multi-phase field model, we analyse the statistical and dynamical properties of T1 transitions in a confluent monolayer. We identify an energy profile that is robust to changes in several model parameters. It is characterized by an asymmetric profile with a fast increase in energy before the T1 transition and a sudden drop after the T1 transition, followed by a slow relaxation. The latter being a signature of the fluidity of the cell monolayer. We show that T1 transitions are sources of localised large deformation of the cells undergoing the neighbour exchange, and they induce other T1 transitions in the nearby cells leading to a chaining of events that propagate local cell deformation to large scale tissue flows.

SUBMITTER: Jain HP

PROVIDER: S-EPMC10284850 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature

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Robust statistical properties of T1 transitions in a multi-phase field model of cell monolayers.

Jain Harish P HP Voigt Axel A Angheluta Luiza L

Scientific reports 20230621 1

Large-scale tissue deformation which is fundamental to tissue development hinges on local cellular rearrangements, such as T1 transitions. In the realm of the multi-phase field model, we analyse the statistical and dynamical properties of T1 transitions in a confluent monolayer. We identify an energy profile that is robust to changes in several model parameters. It is characterized by an asymmetric profile with a fast increase in energy before the T1 transition and a sudden drop after the T1 tra ...[more]

PMID: 37344548

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