A 3-year natural history of orthostatic blood pressure dysregulation in early Parkinson's disease.

ABSTRACT: In Parkinson's disease (PD), cardiovascular dysautonomia accumulates with disease progression, but studies are lacking on the natural history behind each subtype except orthostatic hypotension. This study investigated the early natural history of orthostatic blood pressure (BP) subtypes in PD. Two hundred sixty-seven early PD patients were included. Their cardiovascular functions were assessed by head-up tilt-test and ¹²³I-metaiodobenzylguanidine scintigraphy. All patients were classified as having supine hypertension (SH), orthostatic hypertension (OHT), delayed orthostatic hypotension (dOH), or orthostatic hypotension (OH) according to consensus criteria. The patients were assigned to one of three groups: extreme BP dysregulation (BP_extreme), mild BP dysregulation (

SUBMITTER: Yoo SW 

PROVIDER: S-EPMC10284855 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature